ACTIVTox products are readily available, high-throughput, in vitro human liver assay kits that measure liver toxicity or P450 CYP1A induction. ACTIVTox is a logical alternative to expensive and variable human primary hepatocytes and can effectively replace the in vivo animal testing that is discouraged by the REACH mandate. This system is perfect for early drug discovery and product development as well as the testing of botanical supplements, potentially dangerous chemical substances, and hazardous waste.
Unlike other human liver cell lines, ACTIVTox is built around a stable, highly characterized, patented human liver cell line possessing the functions of an adult liver cell. Capable of gluconeogenesis, it produces liver-specific proteins such as apolipoprotein and albumin, and exhibits Phase II metabolism as well as the appropriate p450 enzymes. The ACTIVTox cells are robust, reproducible, and adaptable to high-throughput assays. These features make ACTIVTox an excellent tool for studying human liver biology.
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